Author

Jennifer Margaret Brisbane

Institute of Genetics and CancerORCID 0000-0003-4943-5331Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 2 Research Focus:protein design· 2 Research Focus:cell type annotation· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1 Assay:scRNA-seq· 1 Organism:zebrafish· 1

Frequent Co-Authors

Andrew J. WoodiD· 2 shared Bin GuiD· 2 shared Gillian C.A. TayloriD· 2 shared Lewis MacdonaldiD· 2 shared Alex von KriegsheimiD· 1 shared Andrew Sofronis PapanastasiouiD· 1 shared Brianda Areli Hernández-MorániD· 1 shared Claudia Ribeiro de AlmeidaiD· 1 shared

Activity by Year

2022-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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2 shared papersMolecular Biology

Andrew J. WoodORCID

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3 papers

Recent·Most cited

Tissue-specific consequences of tag fusions on protein expression in transgenic mice

Gillian C.A. Taylor, Lewis Macdonald, Natalia A. Szulc, Evelina Gudauskaite, Brianda Areli Hernández-Morán, Jennifer Margaret Brisbane, Molly Donald, Ella Taylor, Dejin Zheng, Bin Gu, Pleasantine Mill, Patricia Levy Yeyati, Wojciech Pokrzywa, Claudia Ribeiro de Almeida, Andrew J. Wood

The paper shows that tag fusions can have tissue-specific effects on protein stability in transgenic mice, depending on the cell and tissue environment.

PLoS Genetics · Aug 25, 2025Peer-reviewedMolecular Biology

Unique functions of two overlapping PAX6 retinal enhancers

Kirsty Uttley, Andrew Sofronis Papanastasiou, Manuela Lahne, Jennifer Margaret Brisbane, Ryan B. MacDonald, Wendy A. Bickmore, Shipra Bhatia

The paper identifies distinct cell type-specific functions of two overlapping PAX6 retinal enhancers using live imaging and single-cell RNA sequencing in zebrafish.

bioRxiv · Nov 25, 2022 · PreprintGenetics

Rapid and specific degradation of endogenous proteins in mouse models using auxin-inducible degrons

Lewis Macdonald, Gillian C.A. Taylor, Jennifer Margaret Brisbane, Ersi Christodoulou, Lucy Scott, Alex von Kriegsheim, Janet Rossant, Bin Gu, Andrew J. Wood

This paper develops CRISPR-engineered mouse lines for rapid and specific degradation of endogenous proteins in vivo, revealing stage-specific requirements for condensin complexes in lymphocyte division.

eLife · Jun 23, 2022Peer-reviewedGenetics