Author

Lewis Macdonald

Institute of Genetics and CancerORCID 0000-0002-1512-137XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:protein design· 2 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Andrew J. WoodiD· 2 shared Bin GuiD· 2 shared Gillian C.A. TayloriD· 2 shared Jennifer Margaret BrisbaneiD· 2 shared Alex von KriegsheimiD· 1 shared Brianda Areli Hernández-MorániD· 1 shared Claudia Ribeiro de AlmeidaiD· 1 shared Dejin ZhengiD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersMolecular Biology

Andrew J. WoodORCID

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2 papers

Recent·Most cited

Molecular BiologyPLoS GeneticsPeer-reviewedAug 25, 2025

Tissue-specific consequences of tag fusions on protein expression in transgenic mice

Gillian C.A. Taylor, Lewis Macdonald, Natalia A. Szulc…·Andrew J. Wood

The paper shows that tag fusions can have tissue-specific effects on protein stability in transgenic mice, depending on the cell and tissue environment.

5 citations

mouseprotein structure

𝕏 PostBluesky

GeneticseLifePeer-reviewedJun 23, 2022

Rapid and specific degradation of endogenous proteins in mouse models using auxin-inducible degrons

Lewis Macdonald, Gillian C.A. Taylor, Jennifer Margaret Brisbane…·Andrew J. Wood

This paper develops CRISPR-engineered mouse lines for rapid and specific degradation of endogenous proteins in vivo, revealing stage-specific requirements for condensin complexes in lymphocyte division.

48 citationstop 5%

mouseexperimental assay

𝕏 PostBluesky