Murine Toll-like receptor 8 is a functional sensor of nucleic acid fragments
Lukas Hinkelmann, Mariam Brehm, Victor Wumbor-Apin Kumbol, Hugo McGurran, Christina Krüger, Gunnar Kleinau, Patrick Scheerer, Douglas Taylor Golenbock, Lena Alexopoulou, Michael Paul Gantier, Stefan Bauer, Seija Lehnardt
This study shows that murine TLR8 is a functional nucleic acid sensor, responding to synthetic and endogenous ligands and restoring TLR7-dependent transcriptional programs in vivo.
bioRxiv · Oct 14, 2025 · PreprintImmunology