Author

Seija Lehnardt

Humboldt-Universität zu BerlinORCID 0000-0002-1068-7112Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Immunology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

Christina KrügeriD· 2 shared Douglas Taylor GolenbockiD· 2 shared Gunnar KleinauiD· 2 shared Patrick ScheereriD· 2 shared Andrew G. NewmaniD· 1 shared Bernhard Clemens RichardiD· 1 shared Carola G. SchipkeiD· 1 shared Claus ScheidereitiD· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersImmunology

Christina KrügerORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Murine Toll-like receptor 8 is a functional sensor of nucleic acid fragments

Lukas Hinkelmann, Mariam Brehm, Victor Wumbor-Apin Kumbol, Hugo McGurran, Christina Krüger, Gunnar Kleinau, Patrick Scheerer, Douglas Taylor Golenbock, Lena Alexopoulou, Michael Paul Gantier, Stefan Bauer, Seija Lehnardt

This study shows that murine TLR8 is a functional nucleic acid sensor, responding to synthetic and endogenous ligands and restoring TLR7-dependent transcriptional programs in vivo.

bioRxiv · Oct 14, 2025 · PreprintImmunology

Human endogenous retrovirus HERV-K(HML-2) RNA causes neurodegeneration through Toll-like receptors

Paul Dembny, Andrew G. Newman, Manvendra Singh, Michael Hinz, Michal Szczepek, Christina Krüger, Róbert Adalbert, Omar Dildar a Dzaye, Thorsten Trimbuch, Thomas E. Wallach, Gunnar Kleinau, Katja Derkow, Bernhard Clemens Richard, Carola G. Schipke, Claus Scheidereit, , Seija Lehnardt

This study shows HERV-K(HML-2) RNA activates TLR8 and Tlr7, causing neurodegeneration in mice and correlating with AD in humans.

JCI Insight · Apr 8, 2020Peer-reviewedNeuroscience