Author

Michael Paul Gantier

Hudson Institute of Medical ResearchORCID 0000-0003-3740-698XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Alexandra L. McAllaniD· 2 shared Arwaf S. AlharbiiD· 2 shared Ben CorryiD· 2 shared Daniel S. WenholziD· 2 shared Erandi Rupasinghe· 2 shared Julia I. EllyardiD· 2 shared Kim A. Lennox· 2 shared Liza CubedduiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersImmunology

Alexandra L. McAllanORCID

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3 papers

Recent·Most cited

ImmunologybioRxivPreprintApr 29, 2026

Defining the Immunomodulatory Determinants of 3-mer Oligonucleotides on TLR7 and TLR8 sensing

Sunil Sapkota, Zhikuan Zhang, Christine Wolf…·Michael Paul Gantier

The paper identifies how 3-mer oligonucleotides with base and sugar modifications modulate TLR7 and TLR8 responses, leading to the development of a dual inhibitory oligonucleotide for autoimmune disease.

DOI 10.64898/2026.04.29.720527

experimental assaydeep learning

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ImmunologyNature ImmunologyPeer-reviewedFeb 10, 2026

2'-O-Methyl-guanosine 3-base RNA fragments mediate essential natural TLR7/8 antagonism

Arwaf S. Alharbi, Sunil Sapkota, Zhikuan Zhang…·Michael Paul Gantier

The paper identifies 2'-O-methyl-guanosine RNA fragments as natural antagonists of TLR7/8, preventing auto-immunity by inhibiting TLR signaling.

27 citationstop 1%

humanexperimental assay

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ImmunologybioRxivPreprintOct 14, 2025

Murine Toll-like receptor 8 is a functional sensor of nucleic acid fragments

Lukas Hinkelmann, Mariam Brehm, Victor Wumbor-Apin Kumbol…·Seija Lehnardt

This study shows that murine TLR8 is a functional nucleic acid sensor, responding to synthetic and endogenous ligands and restoring TLR7-dependent transcriptional programs in vivo.

2 citations

mouseexperimental assay

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