Reduction of DNA Topoisomerase Top2 reprograms the epigenetic landscape and extends health and life span across species
Man Zhu, Meng Ma, Lunan Luo, Feiyang Li, Jiashun Zheng, Yan Pan, Lu Yang, Ying Xiao, Ziyan Wang, Bo Xian, Yi Zheng, Hao Li, Jing Chun Yang
This study shows that reducing Top2b extends lifespan and healthspan in multiple species by altering the epigenetic landscape and reversing aging hallmarks.
Aging Cell · Feb 12, 2025Peer-reviewedBiochemistry