BiochemistryAging CellPeer-reviewed
Reduction of DNA Topoisomerase Top2 reprograms the epigenetic landscape and extends health and life span across species
Man Zhu, Meng Ma, Lunan Luo…·Jing Chun Yang
This study shows that reducing Top2b extends lifespan and healthspan in multiple species by altering the epigenetic landscape and reversing aging hallmarks.