Jiashun Zheng

This paper identifies a genetic switch between EZH2 and EGR1 that connects aging and development across human tissues, showing its role in cellular state transitions and rejuvenation.

The paper analyzes single-cell yeast aging trajectories to show proteasome dynamics and nuclear size scaling are key predictors of lifespan and influence mitochondrial morphology.

This study shows that reducing Top2b extends lifespan and healthspan in multiple species by altering the epigenetic landscape and reversing aging hallmarks.

This paper develops a gene-based approach to identify genetic overlaps and shared molecular mechanisms between complex human traits, revealing novel associations and pathways.