Author

Lydia Ambaye

The Scripps Research Institute;

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:Drosophila· 1 Research Focus:drug response / drug discovery· 1 Assay:electronic health records· 1 Organism:human· 1 Assay:metabolomics· 1

Frequent Co-Authors

Alex Matthewson· 1 shared Allison N. BeachumiD· 1 shared Amelia Nachbar· 1 shared Anne-Laure Mahul-Mellier· 1 shared Ariana Maserejian· 1 shared Carl Ash· 1 shared Caroline A. Cuoco· 1 shared Christian M. ColeiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperMolecular Biology

Alex Matthewson

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Autophagy activator AA-20 engages CDK5 to promote lipophagy and improve neurodegeneration-associated phenotypes

Ee Phie Tan, Lydia Ambaye, Anne-Laure Mahul-Mellier, Yuting Zhang, Patricia Martinez-Botia, Sergio R. Labra, Lynee A. Massey, Zi Gao, Zainab Ahmed, Karina Nugroho, Carl Ash, Wen Ren, Christian M. Cole, Yin Wu, Sarah Ly, , Jeffery W. Kelly

AA-20 promotes lipophagy by activating lysosomal acid lipase and CDK5, reducing lipid droplet accumulation and improving neurodegeneration-associated phenotypes in cellular and organoid models.

bioRxiv · Nov 2, 2026 · PreprintMolecular Biology

Glia multitask to compensate for neighboring glial cell dysfunction

Allison N. Beachum, Gabriela Salazar, Amelia Nachbar, Kevin Krause, Hannah Klose, Kate Meyer, Ariana Maserejian, Grace Ross, Hannah Boyd, Thaddeus K. Weigel, Lydia Ambaye, Hayes Miller, Jaeda Coutinho‐Budd

The paper shows that neighboring glial cells compensate for the loss of Spz3 in Drosophila cortex glia by extending processes into the lost territory, while maintaining their normal functions.

bioRxiv · Sep 6, 2024 · PreprintNeuroscience