Karina Nugroho

AA-20 promotes lipophagy by activating lysosomal acid lipase and CDK5, reducing lipid droplet accumulation and improving neurodegeneration-associated phenotypes in cellular and organoid models.

This study uses proteomics and 3D imaging to show that ATTR cardiac amyloidosis involves microangiopathy, capillary occlusion, and vascular basement membrane congestion.

This study uses cryo-EM to reveal the conformational landscape of human transthyretin, uncovering asymmetries and new states relevant to ligand binding and amyloid formation.