AAV serotype PHP.eB achieves superior neuronal transduction efficiency compared to AAV9 in pigtail macaques following intracerebroventricular administration
Michal G. Fortuna, Lyle H. Nyberg, Naz Taskin, Natalie Weed, Avery C. Hunker, Kathryn M. Gudsnuk, Melissa R. Berg, Boaz P. Levi, Ed S. Lein, Jonathan T. Ting
This study compares AAV9 and AAV-PHP.eB transduction efficiency in pigtail macaques, finding AAV-PHP.eB achieves higher rates in cortical and spinal regions.
bioRxiv · Feb 4, 2025 · PreprintNeuroscience