Kathryn M. Gudsnuk

Multimodal characterization of variation in neuronal types in the mouse basal ganglia

This study uses multimodal Patch-seq data to show that gene expression gradients in mouse basal ganglia neurons correlate with spatial location, physiology, and morphology.

Cell type-selective AADC expression reduces motor deficits and dyskinesia in Parkinson's disease mouse models

This study shows that cell type-specific AADC expression in Parkinson's disease models reduces motor deficits and dyskinesia more effectively than broad targeting.

Enhancer AAVs for targeting spinal motor neurons and descending motor pathways in rodents and macaque

The paper identifies enhancers for spinal motor neurons and develops AAV vectors to target these cells in rodents and macaques, enabling functional studies and potential therapeutic applications.

Enhancer AAV toolbox for accessing and perturbing striatal cell types and circuits

The paper presents an enhancer AAV toolbox for targeting and perturbing striatal cell types and circuits in mice, with validated specificity and cross-species applicability.

AAV serotype PHP.eB achieves superior neuronal transduction efficiency compared to AAV9 in pigtail macaques following intracerebroventricular administration

This study compares AAV9 and AAV-PHP.eB transduction efficiency in pigtail macaques, finding AAV-PHP.eB achieves higher rates in cortical and spinal regions.

Sex-specific effects of chronic paternal stress on offspring development are partially mediated via mothers.

This study shows that chronic paternal stress in mice leads to sex-specific effects on offspring behavior, partially mediated through changes in maternal care and investment.

Characterizing nucleotide variation and expansion dynamics in human-specific variable number tandem repeats

The paper characterizes human-specific VNTRs by analyzing their nucleotide composition and expansion dynamics across genomes and populations.