Tom A. P. Driedonks

This paper develops a modular strategy for delivering CRISPR-Cas9 via extracellular vesicles using aptamer-based loading and UV-activated cargo release, demonstrating efficient delivery and versatility in Cas9 variants.

The paper analyzes small RNA-seq data from SARS-CoV-1 and SARS-CoV-2 infected cells to identify novel viral short RNAs and their potential roles in infection.

This study evaluates the accuracy, reproducibility, and bias of small RNA-seq across five protocols and nine labs, finding protocol-specific bias that can be mitigated with adapters and computational corrections.