Kynurenine monooxygenase blockade reduces endometriosis-like lesions, improves visceral hyperalgesia, and rescues mice from a negative behavioural phenotype in experimental endometriosis.
Ben Higgins, Ioannis Simitsidellis, Xiaozhong Zheng, Frances Collins, Natalie Z M Homer, Scott G Denham, Joanna Simpson, Mike Millar, Lyndsey Boswell, Hee Y Lee, Y. G. Kim, Kyung Ho Park, Larry C. Park, Patrick J. Sweeney, Gerard Feraille, , Damian J. Mole
This study shows that blocking Kynurenine monooxygenase (KMO) reduces endometriosis-like lesions, alleviates pain, and improves behavior in a mouse model of endometriosis.
bioRxiv · May 13, 2024 · PreprintPathology