This study identifies two subsets of ILC3 in the human endometrium, showing their distinct roles in repair and regeneration during different physiological states.

Discovery Immunology · Jan 1, 2025Peer-reviewedImmunology

Kynurenine monooxygenase blockade reduces endometriosis-like lesions, improves visceral hyperalgesia, and rescues mice from a negative behavioural phenotype in experimental endometriosis.

Ben Higgins, Ioannis Simitsidellis, Xiaozhong Zheng, Frances Collins, Natalie Z M Homer, Scott G Denham, Joanna Simpson, Mike Millar, Lyndsey Boswell, Hee Y Lee, Y. G. Kim, Kyung Ho Park, Larry C. Park, Patrick J. Sweeney, Gerard Feraille, , Damian J. Mole

This study shows that blocking Kynurenine monooxygenase (KMO) reduces endometriosis-like lesions, alleviates pain, and improves behavior in a mouse model of endometriosis.

bioRxiv · May 13, 2024 · PreprintPathology

Global Endometrial DNA Multi-omics Analysis Reveals Insights into mQTL Regulation and Associated Endometriosis Disease Risk

Sally Mortlock, Sahar Houshdaran, Idit Kosti, Nilüfer Rahmioğlu, CAMRAN R. NEZHAT, Allison F. Vitonis, Shan V. Andrews, Parker Grosjean, Manish D. Paranjpe, Andrew W. Horne, Alison F. Jacoby, Jeannette C. Lager, Jessica Opoku‐Anane, Kim Chi Vo, Evelina Manvelyan, , Linda C. Giudice

The paper analyzes endometrial DNA methylation and genetic variants to identify mQTLs and their association with endometriosis risk and menstrual cycle phases.

bioRxiv · Nov 27, 2022 · PreprintSystems Biology