Damian J. Mole

This study shows that proteostatic failure in ER-phagy, driven by Kras, leads to protein aggregates that prime acinar-ductal metaplasia and pancreatic cancer.

This study shows that blocking Kynurenine monooxygenase (KMO) reduces endometriosis-like lesions, alleviates pain, and improves behavior in a mouse model of endometriosis.

This study investigates the effects of RL-118, an 11β-HSD1 inhibitor, on cognitive and molecular changes induced by chronic mild stress in SAMP8 mice, showing restoration of stress-induced impairments.

The paper identifies four distinct endotypes in acute pancreatitis using multiomic data and clinical metrics, showing diverse molecular and systemic responses.

This study examines recurrence patterns in pancreas cancer patients after surgery, finding that locoregional recurrence is common and linked to R+ resection and venous invasion, with adjuvant chemotherapy improving survival.

The paper identifies shared expression patterns of genetic variants across tissues and cell types, enabling fine mapping of disease-associated variants and revealing key cell types involved in disease pathogenesis.