Author

Ioannis Simitsidellis

MRC Centre for Reproductive HealthORCID 0000-0002-9764-3330Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Assay:flow cytometry· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Philippa T. K. SaundersiD· 2 shared Alessandro Taddei· 1 shared Andrew W. HorneiD· 1 shared Ben Higgins· 1 shared Damian J. MoleiD· 1 shared David Chagras· 1 shared Douglas A GibsoniD· 1 shared Frances CollinsiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersImmunology

Philippa T. K. SaundersORCID

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2 papers

Recent·Most cited

Multimodal Profiling of Repair-Associated Immune Dynamics in a Mouse Model of Menstruation

Rebecca J. Ainslie, Phoebe M. Kirkwood, Hanning Li, Symeon Gerasimou, Philippa T. K. Saunders, Ioannis Simitsidellis, Douglas A Gibson

This study examines immune dynamics during menstruation in mice, identifying monocytes, macrophages, and neutrophils as key players in endometrial repair and highlighting thrombospondin 1 and secreted phosphoprotein 1 as potential therapeutic targets.

Journal of Reproductive Immunology · Oct 1, 2026Peer-reviewedImmunology

Kynurenine monooxygenase blockade reduces endometriosis-like lesions, improves visceral hyperalgesia, and rescues mice from a negative behavioural phenotype in experimental endometriosis.

Ben Higgins, Ioannis Simitsidellis, Xiaozhong Zheng, Frances Collins, Natalie Z M Homer, Scott G Denham, Joanna Simpson, Mike Millar, Lyndsey Boswell, Hee Y Lee, Y. G. Kim, Kyung Ho Park, Larry C. Park, Patrick J. Sweeney, Gerard Feraille, , Damian J. Mole

This study shows that blocking Kynurenine monooxygenase (KMO) reduces endometriosis-like lesions, alleviates pain, and improves behavior in a mouse model of endometriosis.

bioRxiv · May 13, 2024 · PreprintPathology