Author

Scott G Denham

The Queen's Medical Research InstituteORCID 0000-0002-9496-9167Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Pathology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

Joanna P. SimpsoniD· 2 shared Natalie Z M HomeriD· 2 shared Aileen Boyle· 1 shared Alessandro Taddei· 1 shared Alexandra J. MalboniD· 1 shared Alicja CzopekiD· 1 shared Andrew Michael BeekmaniD· 1 shared Andrew W. HorneiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersPhysiology

Joanna P. SimpsonORCID

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2 papers

Recent·Most cited

Carbonyl Reductase 1: a novel regulator of blood pressure in Down Syndrome

Alexandra J. Malbon, Alicja Czopek, Andrew Michael Beekman, Zoë Rachael Goddard, Aileen Boyle, Jessica Ruth Ivy, Kevin Stewart, Scott G. Denham, Joanna P. Simpson, Natalie Z M Homer, Brian Robert Walker, Neeraj Dhaun, Matthew A. Bailey, Ruth A. Morgan

This study identifies CBR1 as a regulator of blood pressure in Down Syndrome, showing that its inhibition can increase blood pressure in a DS mouse model.

Bioscience Reports · Jan 27, 2025Peer-reviewedPhysiology

Kynurenine monooxygenase blockade reduces endometriosis-like lesions, improves visceral hyperalgesia, and rescues mice from a negative behavioural phenotype in experimental endometriosis.

Ben Higgins, Ioannis Simitsidellis, Xiaozhong Zheng, Frances Collins, Natalie Z M Homer, Scott G Denham, Joanna Simpson, Mike Millar, Lyndsey Boswell, Hee Y Lee, Y. G. Kim, Kyung Ho Park, Larry C. Park, Patrick J. Sweeney, Gerard Feraille, , Damian J. Mole

This study shows that blocking Kynurenine monooxygenase (KMO) reduces endometriosis-like lesions, alleviates pain, and improves behavior in a mouse model of endometriosis.

bioRxiv · May 13, 2024 · PreprintPathology