CMTM6-Silencing Microbial Immunotherapy Reprograms PDAC Tumors and Restores T-cell Function
Chiswili Yves Chabu, Robert A. Kazmierczak, M Hasani, Nadia Patterson, Q. Wang, Lorenzo Canti, Mulu Z. Tesfay, Aleksandra Cios, Bakul Dhagat-Mehta, Mar Quereda Pastor, Carmen De La Nuez, Tyler Verburg, Jacob Moyer, K Gunter, Mulunda Mwanza, , Bolni Marius Nagalo
This paper develops iSTORM, a Salmonella-based immunotherapy that silences CMTM6 in PDAC tumors, enhancing T-cell function and tumor control while maintaining safety.
bioRxiv · Jan 28, 2026 · PreprintCancer Biology