Ca2+ influx through ER-plasma membrane contacts is required for brown fat thermogenesis and metabolic health
J Zhou, Cansu Doğan, Leonardo Luís Artico, K Rodrigues, Sophia M. Hakam, T Kim, V. Xu, Kalina Lapenta, M Kang, Danielle M. Jorgens, Scott B. Widenmaier, Güneş Parlakgül, Ana Paula Arruda
This study identifies ER-PM contacts and STIM-mediated SOCE as essential for brown fat thermogenesis and metabolic health during cold exposure.
bioRxiv · Mar 23, 2026 · PreprintCell Biology