Danielle M. Jorgens

This study shows FGF signaling induces disease-associated oligodendrocyte states and causes myelin pathology in both in vitro and in vivo models.

This study identifies miR-34/449 miRNAs as regulators of choroid plexus multiciliogenesis, showing their role in controlling cerebrospinal fluid production through modulation of Shh signaling.

The paper identifies Tom70 as a regulator of nuclear pore complex exclusion during gametogenesis in yeast by mediating mitochondria-nuclear envelope contacts.

This study uses volume EM to reveal the three-dimensional structure of desmosomes in epithelial cells and identifies novel features like discontinuities in the outer dense plaque.

This study shows actin disassembly enables myelin compaction and wrapping in the CNS by developing live-cell assays and genetic perturbations.

This study identifies ER-PM contacts and STIM-mediated SOCE as essential for brown fat thermogenesis and metabolic health during cold exposure.

This study identifies CLCC1 as a regulator of hepatic neutral lipid flux and nuclear pore complex assembly through CRISPR screens and functional analyses.

This study identifies the L260F mutation in NSP6 as enhancing RNA replication and pathogenesis in recent SARS-CoV-2 variants, independent of Spike function.

This study shows that TOMM40 regulates lipid metabolism in hepatocytes through an LXR-dependent pathway, affecting plasma lipid levels and hepatic lipid droplet accumulation.

This study identifies SRF as a transcriptional regulator of cytoskeletal genes in oligodendrocytes essential for myelination during development.