M. Archer

TrkA+ sensory neurons regulate osteosarcoma proliferation and vascularization to promote disease progression

This study shows that TrkA+ sensory neurons promote osteosarcoma progression by enhancing tumor growth, vascularization, and metastasis, and that inhibiting these neurons reduces disease severity and improves survival.

Mapping Somatosensory Afferent Circuitry to Bone Identifies Neurotrophic Signals Required for Fracture Healing

The paper identifies neurotrophic signals, particularly FGF9, required for fracture healing by mapping somatosensory afferent circuitry to bone and analyzing gene expression changes in DRG neurons.

Micronutrient Optimization Using Design of Experiments Approach in Tissue Engineered Articular Cartilage for Production of Type II Collagen

This study uses a Design of Experiments approach with a secreted reporter to optimize micronutrient conditions for enhanced type II collagen expression in engineered cartilage.

Accurate delineation of individual tree crowns in tropical forests from aerial RGB imagery using Mask R-CNN

This paper introduces Detectree2, a deep learning model that accurately segments individual tree crowns in tropical forests from aerial RGB imagery, enabling growth and mortality analysis of large trees.

Age-Related Type I Collagen Modifications Reveal Tissue-Defining Differences Between Ligament and Tendon

This study compares collagen post-translational modifications in bovine tendons and ligaments to identify tissue-specific differences in cross-linking profiles and fibril size.

A Thermostable, Flexible RNA Vaccine Delivery Platform for Pandemic Response

This paper introduces a thermostable RNA vaccine delivery system stable at room temperature for 8+ months and refrigerated for 21+ months, improving vaccine distribution in low-resource settings.

Global elongation and high shape flexibility as an evolutionary hypothesis of accommodating mammalian brains into skulls

The paper analyzes 3D cranial endocasts of marsupials to show brain shape variation is more flexible and less tied to function than previously thought.

Cryo-EM Structures and Regulation of Arabinofuranosyltransferase AftD from Mycobacteria

The paper presents the cryo-EM structure of AftD from M. abscessus and shows its interaction with ACP, revealing potential regulatory mechanisms.