Author

M. A. J. Ferguson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Microbiology· 3 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:cell type annotation· 3 Organism:human· 3 Organism:mouse· 3 Research Focus:gene regulatory network inference· 2 Assay:proteomics· 2 Organism:rat· 2 Assay:ATAC-seq· 1

Frequent Co-Authors

R. Nagar· 4 shared H. Guo· 2 shared S. Damerow· 2 shared S. M. Beverley· 2 shared S. M. Duncan· 2 shared Z. Ji· 2 shared A. Jenni· 1 shared A. K. Menon· 1 shared

Activity by Year

2020-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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4 shared papersBiochemistry

R. Nagar

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Author profile →

7 papers

Recent·Most cited

Identification of the glycosylphosphatidylinositol-specific phospholipase A2 (GPI-PLA2) of GPI fatty acid remodelling in Trypanosoma brucei

Z. Ji, R. Nagar, S. M. Duncan, M. L. Sampaio Guther, M. A. J. Ferguson

This paper identifies a gene encoding GPI-PLA2 in Trypanosoma brucei, showing its role in GPI fatty acid remodelling and anchor sidechain size regulation.

bioRxiv · Apr 18, 2023 · PreprintBiochemistry

Defining Early Steps in B. subtilis Biofilm Biosynthesis

C. A. Arbour, R. Nagar, H. M. Bernstein, S. Ghosh, Y. Al-Sammarraie, H. C. Dorfmueller, M. A. J. Ferguson, N. Stanley-Wall, B. Imperiali

This paper identifies the first two steps in the exopolysaccharide biosynthesis pathway of B. subtilis, determining the substrates for the key enzymes involved.

bioRxiv · Feb 22, 2023 · PreprintMicrobiology

A UDP-GlcNAc : βGal β1-6 GlcNAc transferase involved in bloodstream form N-glycan and procyclic form GPI anchor elaboration in Trypanosoma brucei.

S. M. Duncan, R. Nagar, M. Damerow, D. V. Yashunsky, B. Buzzi, A. V. Nikolaev, M. A. J. Ferguson

This paper identifies TbGT10 as a UDP-GlcNAc:βGal β1-6 GlcNAc-transferase essential for N-glycan and GPI anchor modifications in Trypanosoma brucei.

bioRxiv · Jun 21, 2021 · PreprintBiochemistry

An essential, kinetoplastid-specific GDP-Fuc: β-D-Gal α-1,2-fucosyltransferase is located in the mitochondrion of Trypanosoma brucei

G. Bandini, S. Damerow, M. L. Sempaio Güther, H. Guo, A. Mehlert, S. M. Beverley, M. A. J. Ferguson

This study identifies TbFUT1 as an essential mitochondrial fucosyltransferase in Trypanosoma brucei, critical for both bloodstream and procyclic forms and potentially therapeutically relevant across trypanosomatids.

bioRxiv · May 11, 2021Microbiology

A broadly active fucosyltransferase LmjFUT1 whose mitochondrial localization and catalytic activity is essential in the parasitic protozoan Leishmania

H. Guo, S. Damerow, L. Penha, S. Menzies, G. Polanco, H. Zegzouti, M. A. J. Ferguson, S. M. Beverley

This paper identifies FUT1 as an essential fucosyltransferase in Leishmania, localized to mitochondria, with enzymatic activity required for viability and mitochondrial function.

bioRxiv · May 10, 2021Microbiology

Elimination of GPI2 suppresses glycosylphosphatidylinositol GlcNAc transferase activity and alters GPI glycan modification in Trypanosoma brucei

A. Jenni, S. Knüsel, R. Nagar, M. Benninger, R. Häner, M. A. J. Ferguson, I. Roditi, A. K. Menon, P. Bütikofer

This study shows that eliminating GPI2 in Trypanosoma brucei reduces GPI GlcNAc transferase activity, alters GPI glycan modification, and affects social motility.

bioRxiv · Mar 18, 2021Biochemistry

Proteomic identification of the UDP-GlcNAc : PI α1-6 GlcNAc-transferase subunits of the glycosylphosphatidylinositol biosynthetic pathway of .

Z. Ji, M. Tinti, M. A. J. Ferguson

The paper identifies subunits of the UDP-GlcNAc : PI α1-6 GlcNAc-transferase complex in Trypanosoma brucei using proteomics and immunoprecipitation.

bioRxiv · Dec 16, 2020Pathology