Author

H. C. Dorfmueller

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Assay:proteomics· 4 Organism:human· 3 Organism:bacteria (other)· 2 Research Focus:cell type annotation· 2 Organism:mouse· 2 Organism:Arabidopsis· 1 Approach:biophysical modeling· 1

Frequent Co-Authors

B. H. Meyer· 3 shared S. Ajay Castro· 3 shared A. Zorzoli· 2 shared N. Korotkova· 2 shared N. M. van Sorge· 2 shared A. Arunrao Pohane· 1 shared A. B. Herr· 1 shared A. E. Yarawsky· 1 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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3 shared papersMicrobiology

B. H. Meyer

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Defining Early Steps in B. subtilis Biofilm Biosynthesis

C. A. Arbour, R. Nagar, H. M. Bernstein, S. Ghosh, Y. Al-Sammarraie, H. C. Dorfmueller, M. A. J. Ferguson, N. Stanley-Wall, B. Imperiali

This paper identifies the first two steps in the exopolysaccharide biosynthesis pathway of B. subtilis, determining the substrates for the key enzymes involved.

bioRxiv · Feb 22, 2023 · PreprintMicrobiology

Recombinant Group A Carbohydrate backbone embedded into Outer Membrane Vesicles is a potent vaccine candidate targeting Group A Streptococcus from Streptococcus pyogenes and Streptococcus dysgalactiae subsp. equisimilis

S. Ajay Castro, S. Thomson, A. Zorzoli, B. H. Meyer, M. Reglinski, H. C. Dorfmueller

This study demonstrates that recombinant polyrhamnose (pRha) embedded in outer membrane vesicles (OMVs) induces potent antibodies against Group A Streptococcus, effectively killing hypervirulent strains.

bioRxiv · Nov 12, 2021 · PreprintMicrobiology

Molecular basis for recognition of the Group A Carbohydrate backbone by the PlyC streptococcal bacteriophage endolysin

H. King, S. Ajay Castro, A. Arunrao Pohane, C. M. Scholte, V. A. Fischetti, N. Korotkova, D. C. Nelson, H. C. Dorfmueller

This study identifies the molecular interaction between the PlyCB CBD of the PlyC endolysin and the pRha backbone of Group A Streptococcus and Streptococcus mutans cell wall polysaccharides.

Biochemical Journal · Jun 25, 2021Peer-reviewedBiochemistry

N-glycan chitobiose core biosynthesis by Agl24 strengthens the hypothesis of an archaeal origin of the eukaryal N-glycosylation

B. H. Meyer, B. A. Wagstaff, P. S. Adam, S.-V. Albers, H. C. Dorfmueller

This paper identifies and characterizes Agl24, an archaeal enzyme involved in N-glycan chitobiose core biosynthesis, supporting the hypothesis of an archaeal origin of eukaryotic N-glycosylation.

bioRxiv · Jan 19, 2021Microbiology

Modification of cell wall polysaccharide spatially controls cell division in Streptococcus mutans

S. Zamakhaeva, C. T. Chaton, J. S. Rush, S. Ajay Castro, A. E. Yarawsky, A. B. Herr, N. M. van Sorge, H. C. Dorfmueller, G. I. Frolenkov, K. V. Korotkov, N. Korotkova

This study shows that GroP-deficient immature SCCs spatially coordinate AtlA and MapZ localization in S. mutans, ensuring proper cell division and morphology.

bioRxiv · Jun 26, 2020Microbiology

Streptococcal dTDP-L-rhamnose biosynthesis enzymes: functional characterization and lead compound identification

S. L. van der Beek, A. Zorzoli, E. Canak, R. N. Chapman, B. H. Meyer, G.-J. P. H. Boons, H. C. Dorfmueller, N. M. van Sorge

This study functionally characterizes dTDP-L-rhamnose biosynthesis enzymes in Streptococcus pyogenes and identifies Ri03 as a lead compound inhibiting growth of GAS and related pathogens.

bioRxiv · Jun 22, 2018Microbiology