SARS-CoV-2 induces double-stranded RNA-mediated innate immune responses in respiratory epithelial derived cells and cardiomyocytes
Y. Li, D. Renner, C. E. Comar, J. Whelan, H. Reyes, F. L. Cardenas-Diaz, R. Truitt, L. H. Tan, B. Dong, K. D. Alysandratose, J. Huang, J. N. Palmer, N. D. Adappa, M. A. Kohanski, D. N. Kotton, , S. R. Weiss
This study investigates how SARS-CoV-2 interacts with host antiviral pathways in respiratory and cardiac cells, finding it activates OAS-RNase L and PKR but not IFN, contrasting with MERS-CoV.
bioRxiv · Sep 24, 2020Microbiology