Author

L. H. Tan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 5 Organism:human· 5 Assay:bulk RNA-seq· 3 Research Focus:drug response / drug discovery· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

S. R. Weiss· 5 shared N. A. Cohen· 3 shared A. Fausto· 2 shared C. Otter· 2 shared D. Renner· 2 shared N. Cohen· 2 shared A. D. Marques· 1 shared A. Fehr· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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5 shared papersMicrobiology

S. R. Weiss

Mutual co-authors in cluster

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5 papers

Recent·Most cited

Interferon signaling in the nasal epithelium distinguishes among lethal and common cold respiratory viruses and is critical for viral clearance

C. J. Otter, D. M. Renner, A. Fausto, L. H. Tan, N. A. Cohen, S. R. Weiss

The paper examines how interferon signaling in nasal epithelial cells differentiates between common cold and lethal respiratory viruses, showing its role in viral clearance.

bioRxiv · Dec 18, 2023 · PreprintMicrobiology

Comparison of SARS-CoV-2 variants of concern in primary human nasal cultures demonstrates Delta as most cytopathic and Omicron as fastest replicating

N. S. Tanneti, A. K. Patel, L. H. Tan, A. D. Marques, R. A. Perera, S. Sherrill-Mix, B. J. Kelly, R. G. Collman, K. Rodino, C. Lee, F. D. Bushman, N. A. Cohen, S. R. Weiss

The paper compares SARS-CoV-2 variants of concern in nasal and lung cultures, finding Omicron replicates fastest and Delta causes most cellular damage.

bioRxiv · Aug 24, 2023Microbiology

Infection of primary nasal epithelial cells differentiates among lethal and seasonal human coronaviruses

C. Otter, A. Fausto, L. H. Tan, N. A. Cohen, S. R. Weiss

This study compares the infection effects of lethal and seasonal human coronaviruses in nasal epithelial cells, finding differences in cytotoxicity and barrier disruption.

bioRxiv · Oct 17, 2022Microbiology

MERS-CoV endoribonuclease and accessory proteins jointly evade host innate immunity during infection of lung and nasal epithelial cells

C. Comar, C. Otter, J. Pfannenstiel, E. Doerger, D. Renner, L. H. Tan, S. Perlman, N. Cohen, A. Fehr, S. R. Weiss

This study shows that MERS-CoV's EndoU and accessory proteins NS4a/NS4b together suppress innate immunity, enabling viral replication, unlike SARS-CoV-2 which activates these pathways.

bioRxiv · Dec 20, 2021 · PreprintMicrobiology

SARS-CoV-2 induces double-stranded RNA-mediated innate immune responses in respiratory epithelial derived cells and cardiomyocytes

Y. Li, D. Renner, C. E. Comar, J. Whelan, H. Reyes, F. L. Cardenas-Diaz, R. Truitt, L. H. Tan, B. Dong, K. D. Alysandratose, J. Huang, J. N. Palmer, N. D. Adappa, M. A. Kohanski, D. N. Kotton, , S. R. Weiss

This study investigates how SARS-CoV-2 interacts with host antiviral pathways in respiratory and cardiac cells, finding it activates OAS-RNase L and PKR but not IFN, contrasting with MERS-CoV.

bioRxiv · Sep 24, 2020Microbiology