Author

C. C. Liu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Bioengineering· 2 Cancer Biology· 1 Immunology· 1 Pathology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Organism:human· 3 Assay:imaging· 2 Approach:machine learning (classical)· 2 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Research Focus:benchmarking· 1

Frequent Co-Authors

M. Angelo· 3 shared A. Kong· 2 shared A. Wellner· 2 shared D. S. Marks· 2 shared J.-E. Shin· 2 shared S. C. Bendall· 2 shared A. Baranski· 1 shared A. C. Kagel· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersImmunology

M. Angelo

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Atomically accurate de novo design of antibodies with RFdiffusion

N. R. Bennett, J. L. Watson, R. J. Ragotte, A. J. Borst, D. L. See, C. Weidle, R. Biswas, Y. Yu, E. L. Shrock, R. Ault, P. J. Y. Leung, B. Huang, I. Goreshnik, J. Tam, K. D. Carr, , D. Baker

This paper designs antibodies de novo with atomic precision using RFdiffusion and yeast display, validated by cryo-EM and biophysical methods.

bioRxiv · Mar 14, 2024Bioengineering

Dynamic CD8+ T cell responses to cancer immunotherapy in human regional lymph nodes are disrupted by metastasis

M. K. Rahim, T. L. H. Okholm, K. B. Jones, E. E. McCarthy, C. C. Liu, J. L. Yee, S. J. Tamaki, D. M. Marquez, I. Tenvooren, K. Wai, A. Cheung, B. R. Davidson, V. Johri, B. Samad, W. E. O'Gorman, , M. H. Spitzer

The paper examines CD8+ T cell responses in human lymph nodes during cancer immunotherapy and finds that metastasis disrupts these responses.

bioRxiv · Nov 8, 2022 · PreprintImmunology

An in silico method to assess antibody fragment polyreactivity

E. P. Harvey, J.-E. Shin, M. A. Skiba, G. R. Nemeth, J. D. Hurley, A. Wellner, A. Y. Shaw, V. G. Miranda, J. K. Min, C. C. Liu, D. S. Marks, A. Kruse

The paper develops a machine learning model to assess and reduce polyreactivity in nanobody sequences, achieving high accuracy and practical application through a web server.

bioRxiv · Jan 12, 2022 · PreprintPharmacology & Toxicology

Reproducible, high-dimensional imaging in archival human tissue by Multiplexed Ion Beam Imaging by Time-of-Flight (MIBI-TOF)

C. C. Liu, M. Bosse, A. Kong, A. Kagel, R. Kinders, S. M. Hewitt, S. C. Bendall, M. Angelo

This study validates MIBI-TOF for consistent, high-dimensional imaging in archival human tissue, showing high concordance with single-plex IHC and automated cell population analysis.

bioRxiv · Oct 14, 2021Pathology

Transition to invasive breast cancer is associated with progressive changes in the structure and composition of tumor stroma

T. Risom, D. R. Glass, C. C. Liu, B. Rivero-Gutierrez, A. Baranski, E. F. McCaffrey, N. F. Greenwald, A. C. Kagel, S. H. Strand, S. Varma, A. Kong, L. Keren, S. Srivastava, C. Zhu, Z. Khair, , M. Angelo

The paper analyzes tumor microenvironment changes from normal to invasive breast cancer using imaging and machine learning, finding coordinated shifts in stromal cell location and function.

bioRxiv · Jan 5, 2021Cancer Biology

Rapid generation of potent antibodies by autonomous hypermutation in yeast

A. Wellner, C. McMahon, M. S. A. Gilman, J. R. Clements, S. Clark, K. M. Nguyen, M. H. Ho, J.-E. Shin, J. Feldman, B. M. Hauser, T. M. Caradonna, L. M. Wingler, A. G. Schmidt, D. S. Marks, J. Abraham, , C. C. Liu

This paper introduces AHEAD, a yeast-based system for rapid antibody generation through autonomous hypermutation, achieving high-affinity antibodies against SARS-CoV-2 and other targets in just 2 weeks.

bioRxiv · Nov 11, 2020Bioengineering