A. Kruse

Mutant GNAS drives a pyloric metaplasia with tumor suppressive glycans in intraductal papillary mucinous neoplasia

This study identifies GNASR201C as a driver of pyloric metaplasia in IPMN, characterized by tumor-suppressive glycans that inhibit cancer progression.

AlphaFold2 structures template ligand discovery

This study evaluates AlphaFold2 models for ligand discovery, finding they perform similarly to experimental structures despite conformational differences, and identify potent agonists for the 5-HT2A receptor.

Circulating immune cell populations at rest and in response to acute endurance exercise in young adults with cerebral palsy

This study compares immune cell populations in young adults with cerebral palsy and typically developing individuals before, immediately after, and one hour following acute endurance exercise.

An in silico method to assess antibody fragment polyreactivity

The paper develops a machine learning model to assess and reduce polyreactivity in nanobody sequences, achieving high accuracy and practical application through a web server.

Dormant spores sense amino acids through the B subunits of their germination receptors

The paper identifies GerAB as the L-alanine sensor in spores, showing mutations in its ligand-binding pocket impair germination and substitutions enable response to other amino acids.

Phospholipidosis is a shared mechanism underlying the in vitro antiviral activity of many repurposed drugs against SARS-CoV-2

A dynamic interaction between CD19 and the tetraspanin CD81 controls B cell co-receptor trafficking

This study shows that CD81 controls CD19 trafficking to the cell surface through a dynamic interaction, with implications for B cell function and tetraspanin biology.