Author

M. K. Lehtinen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1

Frequent Co-Authors

A. Abdeltawab· 1 shared A. C. Kruse· 1 shared A. Hill· 1 shared A. Jassim· 1 shared A. Patrizi· 1 shared A. Regev· 1 shared B. Terre· 1 shared B. V. Nimmervoll· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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1 shared paperCancer Biology

A. Abdeltawab

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Author profile →

3 papers

Recent·Most cited

Natural language processing charts transcriptome evolution to design combination cancer therapies

A. Jassim, B. V. Nimmervoll, S. Terranova, E. Nathan, K. E. Masih, L. Ruff, M. Duarte, E. Cooper, L. P. Hu, G. Katyal, M. Akhbari, R. J. Gilbertson, C. Terhune, G. Balmus, S. P. Jackson, , R. J. Gilbertson

This paper introduces RECODR, a computational pipeline that tracks transcriptome changes in cancer development and treatment to predict resistance mechanisms and design effective therapies.

bioRxiv · Apr 9, 2024 · PreprintCancer Biology

Antibodies Expand the Scope of Angiotensin Receptor Pharmacology

M. A. Skiba, S. M. Sterling, S. Rawson, M. S. A. Gilman, H. Xu, G. R. Nemeth, J. D. Hurley, P. Shen, D. P. Staus, J. Kim, C. McMahon, M. K. Lehtinen, L. M. Wingler, A. C. Kruse

This study develops nanobody antagonists against the AT1R receptor, showing they can selectively bind and modulate the receptor with tunable ligand selectivity.

bioRxiv · Aug 23, 2023Pharmacology & Toxicology

GEMC1-MCIDAS transcriptional program regulates multiciliogenesis in the choroid plexus and acts as a barrier to tumorigenesis

Q. Li, Z. Han, N. Singh, B. Terre, R. M. Fame, U. Arif, T. D. Page, T. Zahran, A. Abdeltawab, Y. Huang, P. Cao, J. Wang, H. Lu, H. G. W. Lidov, K. Surendran, , H. Zhao

This study identifies the GEMC1-MCIDAS transcriptional program as essential for multiciliogenesis in the choroid plexus and its role in preventing tumorigenesis.

bioRxiv · Nov 22, 2020 · PreprintCancer Biology