CRISPR base editing of cis-regulatory elements enables target gene perturbations
C. K. W. Lim, T. X. McCallister, C. Saporito-Magrina, G. D. McPheron, R. Krishnan, M. A. Zeballos, J. E. Powell, L. V. Clark, P. Perez-Pinera, T. Gaj
This study shows CRISPR base editors can reduce gene expression by editing cis-regulatory elements, with examples in human and mouse models.
bioRxiv · May 26, 2022 · PreprintBioengineering