Author

C. K. W. Lim

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Bioengineering· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:genetic perturbation / CRISPR· 2 Organism:mouse· 2 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Research Focus:perturbation response prediction· 1

Frequent Co-Authors

J. E. Powell· 2 shared T. Gaj· 2 shared T. X. McCallister· 2 shared C. Saporito-Magrina· 1 shared G. D. McPheron· 1 shared L. V. Clark· 1 shared M. A. Z. C.· 1 shared M. A. Zeballos· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersBioengineering

J. E. Powell

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

A high-fidelity CRISPR-Cas13 system improves abnormalities associated with C9ORF72-linked ALS/FTD

T. X. McCallister, C. K. W. Lim, W. M. Terpstra, M. A. Z. C., S. Zhang, J. E. Powell, T. Gaj

This study develops a high-fidelity CRISPR-Cas13 system that reduces C9ORF72 repeat RNA expression in a rodent model, decreasing RNA foci and reversing transcriptional deficits without affecting normal C9ORF72 levels.

bioRxiv · Dec 12, 2023Bioengineering

CRISPR base editing of cis-regulatory elements enables target gene perturbations

C. K. W. Lim, T. X. McCallister, C. Saporito-Magrina, G. D. McPheron, R. Krishnan, M. A. Zeballos, J. E. Powell, L. V. Clark, P. Perez-Pinera, T. Gaj

This study shows CRISPR base editors can reduce gene expression by editing cis-regulatory elements, with examples in human and mouse models.

bioRxiv · May 26, 2022 · PreprintBioengineering