Author

T. X. McCallister

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Approach:genetic perturbation / CRISPR· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

C. K. W. Lim· 2 shared J. E. Powell· 2 shared T. Gaj· 2 shared C. Cotton· 1 shared C. Saporito-Magrina· 1 shared D. Dacus· 1 shared E. Rigiofoirate· 1 shared G. D. McPheron· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersBioengineering

C. K. W. Lim

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

A high-fidelity CRISPR-Cas13 system improves abnormalities associated with C9ORF72-linked ALS/FTD

T. X. McCallister, C. K. W. Lim, W. M. Terpstra, M. A. Z. C., S. Zhang, J. E. Powell, T. Gaj

This study develops a high-fidelity CRISPR-Cas13 system that reduces C9ORF72 repeat RNA expression in a rodent model, decreasing RNA foci and reversing transcriptional deficits without affecting normal C9ORF72 levels.

bioRxiv · Dec 12, 2023Bioengineering

CRISPR base editing of cis-regulatory elements enables target gene perturbations

C. K. W. Lim, T. X. McCallister, C. Saporito-Magrina, G. D. McPheron, R. Krishnan, M. A. Zeballos, J. E. Powell, L. V. Clark, P. Perez-Pinera, T. Gaj

This study shows CRISPR base editors can reduce gene expression by editing cis-regulatory elements, with examples in human and mouse models.

bioRxiv · May 26, 2022 · PreprintBioengineering

β-HPV 8E6 Dysregulates the Hippo Signaling Pathway and Induces Aneuploidy

D. Dacus, T. X. McCallister, C. Cotton, E. Rigiofoirate, N. A. Wallace

This paper shows that β-HPV 8E6 disrupts the Hippo signaling pathway, leading to increased cell growth and aneuploidy, and synergizes with telomerase activation to promote genomic instability.

bioRxiv · Sep 6, 2019 · PreprintCancer Biology