R. Krishnan

CRISPR base editing of cis-regulatory elements enables target gene perturbations

This study shows CRISPR base editors can reduce gene expression by editing cis-regulatory elements, with examples in human and mouse models.

Pentosan polysulfate inhibits attachment and infection by SARS-CoV-2 in vitro: insights into structural requirements for binding.

This study shows that pentosan polysulfate inhibits SARS-CoV-2 attachment and infection in vitro, with effectiveness comparable to heparin and better than low molecular weight heparin.

Spatiotemporal solidification of α-synuclein inside the liquid droplets

This study investigates the spatiotemporal solidification of α-synuclein within liquid droplets, showing how solid-like cores form and propagate during droplet aging and fusion.

Role of non-specific interactions in the phase-separation and maturation of macromolecules

This paper investigates how non-specific interactions influence phase separation and maturation of polymers, showing an optimal range of interaction strengths for forming functional biomolecular complexes.

Comparative Transcriptome Profiling of High and Low oil yielding Santalum album L.

This study compares transcriptomes of high and low oil yielding Santalum album trees to identify genes involved in oil biosynthesis.

Lysyl oxidase-like 2 (LOXL2) is Increased in Asthma and Contributes to Asthmatic Airway Remodelling

This study shows LOXL2 is increased in asthma and contributes to airway remodelling by enhancing TGFβ activation and ECM stiffness.

Acylcarnitine Metabolomic Profiles Inform Clinically-Defined Major Depressive Phenotypes

This study identifies distinct acylcarnitine metabolomic profiles associated with different subtypes of major depressive disorder following SSRI treatment.

Extracellular matrix stiffness regulates force transmission pathways in multicellular ensembles of human airway smooth muscle cells.

This study shows ECM stiffness regulates force transmission in human airway smooth muscle cell ensembles by switching between ECM and cell-cell force transmission pathways.

Traction force screening enabled by compliant PDMS elastomers

This paper introduces a high-throughput traction force screening method using compliant PDMS elastomers to measure cell contractility in multiple cell types.