Author

M. Affolter

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Biochemistry· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:Drosophila· 2 Research Focus:protein folding & dynamics· 2 Assay:protein structure· 2 Organism:zebrafish· 2 Research Focus:cell-cell communication· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:comparative / phylogenetic analysis· 1

Frequent Co-Authors

G. Aguilar· 2 shared H.-G. Belting· 2 shared M. A. Vigano· 2 shared M. P. Kotini· 2 shared S. Matsuda· 2 shared A. Plueckthun· 1 shared A. Schmidt· 1 shared A. Spang· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersBiochemistry

G. Aguilar

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Genetic analysis of rab7 mutants in zebrafish

D. Heutschi, E. Schmelzer, V. Aydogan, A. Schmidt, H.-G. Belting, A. Spang, M. Affolter, M. P. Kotini

This study investigates the role of Rab7 genes in zebrafish vascular development, showing their involvement in lumen formation and identifying functional redundancy and maternal contributions.

bioRxiv · Mar 9, 2023 · PreprintGenetics

Vinculin controls endothelial cell junction dynamics during vascular lumen formation

M. P. Kotini, M. M. van der Stoel, M. K. Han, B. Kirchmaier, J. de Rooij, M. Affolter, S. Huveneers, H.-G. Belting

This study shows vinculin regulates junctional finger formation in endothelial cells during vascular lumen formation in zebrafish by responding to mechanical forces.

bioRxiv · Mar 8, 2021Cell Biology

A new perspective on the evolution of the interaction between the Vg/VGLL1-3 proteins and the TEAD transcription factors

Y. Mesrouze, G. Aguilar, F. Bokhovchuk, T. Martin, C. Martin, F. Villard, M. Meyerhofer, C. Zimmermann, P. Fontana, R. Wille, T. Vorherr, D. Erdmann, P. Furet, C. Scheufler, T. Schmelzle, , P. Chene

The paper investigates the structural and functional evolution of Vg/VGLL1-3 proteins' interaction with TEAD transcription factors, revealing an additional {Omega}-loop in some variants.

bioRxiv · May 21, 2020Biochemistry

Protein manipulation using single copies of short peptide tags in cultured cells and in Drosophila melanogaster

M. A. Vigano, C.-M. Ell, M. M. Kustermann, G. Aguilar, S. Matsuda, N. Zhao, T. J. Stasevich, G. Pyrowolakis, M. Affolter

The paper demonstrates that single copies of short peptide tags can enable protein binding and manipulation in cultured cells and Drosophila, allowing degradation and relocalization of proteins of interest in vivo.

bioRxiv · Apr 6, 2020Cell Biology

DARPins recognizing mTFP1 as novel reagents for in vitro and in vivo protein manipulations

M. A. Vigano, D. Bieli, J. V. Schaefer, R. P. Jakob, S. Matsuda, T. Maier, A. Plueckthun, M. Affolter

This paper generates DARPins targeting mTFP1 and uses them to delocalize Rab proteins in cultured cells, demonstrating potential for direct protein manipulation in vivo.

bioRxiv · Jun 22, 2018Cell Biology