Author

J. V. Schaefer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

A. Plueckthun· 3 shared B. Dreier· 2 shared A. G. Reidenbach· 1 shared A. M. E. Faust· 1 shared A.-N. Bondar· 1 shared B. I. C. Tresco· 1 shared B. K. Hua· 1 shared B. Khanppnavar· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersCell Biology

A. Plueckthun

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Author profile →

4 papers

Recent·Most cited

Diversity-oriented synthesis encoded by deoxyoligonucleotides

L. Hudson, J. W. Mason, M. V. Westphal, M. J. R. Richter, J. R. Thielman, B. K. Hua, C. J. Gerry, G. Xia, H. L. Osswald, J. M. Knapp, Z. Y. Tan, P. Kokkonda, B. I. C. Tresco, S. Liu, A. G. Reidenbach, , K. Briner

The paper describes the design, synthesis, and validation of a 3.7 million-member DNA-encoded library using diversity-oriented synthesis to enhance structural diversity for drug discovery.

bioRxiv · Oct 16, 2022Biochemistry

Nuclear myosin VI maintains replication fork stability

J. Shi, K. Hauschulte, I. Mikicic, S. Maharjan, V. Arz, J. B. Heidelberger, J. V. Schaefer, B. Dreier, A. Plueckthun, P. Beli, H. D. Ulrich, H.-P. Wollscheid

This study shows that nuclear myosin VI stabilizes stalled or reversed replication forks by interacting with WRNIP1 to prevent DNA2-mediated degradation during replication stress.

bioRxiv · Jul 28, 2022Cell Biology

Structural basis of adenylyl cyclase 9 activation

C. Qi, P. Lavriha, V. Mehta, B. Khanppnavar, I. Mohammed, Y. Li, M. Lazaratos, J. V. Schaefer, B. Dreier, A. Plueckthun, A.-N. Bondar, C. W. Dessauer, V. M. Korkhov

The paper presents cryo-EM structures of AC9 in different states to reveal activator-induced conformational changes essential for its activation.

bioRxiv · Aug 11, 2021Biochemistry

DARPins recognizing mTFP1 as novel reagents for in vitro and in vivo protein manipulations

M. A. Vigano, D. Bieli, J. V. Schaefer, R. P. Jakob, S. Matsuda, T. Maier, A. Plueckthun, M. Affolter

This paper generates DARPins targeting mTFP1 and uses them to delocalize Rab proteins in cultured cells, demonstrating potential for direct protein manipulation in vivo.

bioRxiv · Jun 22, 2018Cell Biology