M. B. Goldberg

Longitudinal characterization of circulating neutrophils uncovers distinct phenotypes associated with disease severity in hospitalized COVID-19 patients

This study identifies distinct neutrophil phenotypes linked to disease severity in hospitalized COVID-19 patients using longitudinal data and multi-omics analyses.

Pattern Recognition Receptor for Bacterial Lipopolysaccharide in the Cytosol of Human Macrophages

The paper identifies NLRP11 as a cytosolic receptor for bacterial lipopolysaccharide in human macrophages, essential for caspase-4 inflammasome activation.

Topology and contribution to the pore channel lining of plasma membrane-embedded S. flexneri type 3 secretion translocase IpaB

The paper maps the topology of IpaB in Shigella translocons and shows its role in forming the pore channel for virulence protein delivery.

The Shigella type III effector protein OspB is a cysteine protease

This paper identifies OspB as a cysteine protease in Shigella spp. and shows it interacts with the TORC1 pathway in yeast through proteolytic cleavage of Tco89p.

The type 3 secretion system requires actin polymerization to open translocon pores

This study shows actin polymerization is required for T3SS translocon pore opening, enabling effector translocation, but not for docking or membrane insertion.

Early cross-coronavirus reactive signatures of protective humoral immunity against COVID-19

The paper profiles early humoral immune responses in COVID-19 patients, finding that survivors show rapid SARS-CoV-2-specific immunity linked to pre-existing OC43 immunity, while non-survivors have delayed and blunted responses.

Induction of a regulatory myeloid program in bacterial sepsis and severe COVID-19

The paper identifies a regulatory myeloid program, MS1, associated with sepsis mortality and up-regulated in severe COVID-19, showing its immunosuppressive role and cytokine-dependent induction.

Shigella flexneri disruption of host cell-cell tension promotes intercellular spread

This study shows that Shigella flexneri uses IpaC to reduce cell-cell tension, enabling intercellular spread by forming protrusions.

Activation of Shigella flexneri type 3 secretion requires a host-induced conformational change to the translocon pore

This paper shows that host intermediate filaments induce conformational changes in the Shigella T3SS pore, enabling docking and effector secretion.

Topological analysis of the type 3 secretion system translocon pore protein IpaC following its native delivery to the plasma membrane during infection

The paper determines the topology of IpaC and SipC translocon pore proteins in their native context during infection, resolving conflicting data and identifying topological differences that may underlie functional divergence.