Author

M. B. Ortigoza

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 5 Organism:mouse· 4 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:proteomics· 2 Research Focus:cell-cell communication· 1

Frequent Co-Authors

J. N. Weiser· 3 shared C. Loomis· 2 shared G. Ciabattoni· 2 shared R. Duerr· 2 shared A. Hammond· 1 shared A. Heguy· 1 shared A. J. Hammond· 1 shared A. M. Valero-Jimenez· 1 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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3 shared papersMicrobiology

J. N. Weiser

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Author profile →

6 papers

Recent·Most cited

Targeting host sialic acids in the upper respiratory tract with a broadly-acting neuraminidase to inhibit influenza virus transmission

M. B. Ortigoza, C. L. Mobini, H. L. Rocha, S. Bartlett, C. A. Loomis, J. N. Weiser

This study demonstrates that blocking both 2,3- and 2,6-sialic acid receptors in infant mice using a broadly-acting neuraminidase inhibits influenza virus transmission.

bioRxiv · Jun 2, 2023 · PreprintMicrobiology

Inflammation durably imprints memory CD4+ T cells

S. L. Gray-Gaillard, S. Solis, H. Chen, C. Monteiro, G. Ciabattoni, M. I. Samanovic, A. R. Cornelius, T. Williams, E. Geesey, M. Rodriguez, M. B. Ortigoza, E. N. Ivanova, S. B. Koralov, M. J. Mulligan, R. S. Herati

This study compares transcriptional and epigenetic differences in Spike-specific CD4+ T cell memory between individuals primed by SARS-CoV-2 infection versus mRNA vaccination.

bioRxiv · Nov 15, 2022 · PreprintImmunology

A neonatal mouse model characterizes transmissibility of SARS-CoV-2 variants and reveals a role for ORF8

B. A. Rodriguez-Rodriguez, G. Ciabattoni, R. Duerr, A. M. Valero-Jimenez, S. T. Yeung, K. M. Crosse, A. Schinlever, L. Bernard-Raichon, J. J. Rodriguez-Galvan, M. McGrath, S. Vashee, Y. Xue, C. Loomis, K. M. Khanna, K. H. Cadwell, , M. Dittmann

This study establishes a neonatal mouse model to study SARS-CoV-2 transmissibility, showing variant differences in infectious shedding and identifying ORF8's role in transmission.

bioRxiv · Oct 4, 2022 · PreprintMicrobiology

Delta-Omicron recombinant escapes therapeutic antibody neutralization

R. Duerr, H. Zhou, T. Tada, D. Dimartino, C. Marier, P. Zappile, G. Wang, J. Plitnick, S. Griesemer, R. C. Girardin, J. Machowski, S. Bialosuknia, E. Lasek-Nesselquist, S. L. Hong, G. Baele, , A. Heguy

This study identifies a Delta-Omicron recombinant SARS-CoV-2 variant that escapes Sotrovimab neutralization, highlighting the role of recombination in immune escape.

bioRxiv · Apr 6, 2022Microbiology

Neuraminidase B controls neuraminidase A-dependent mucus production and evasion

A. J. Hammond, U. Binsker, S. D. Aggarwal, M. B. Ortigoza, C. Loomis, J. N. Weiser

This study identifies the role of neuraminidase B in mucus evasion and mucus production by Streptococcus pneumoniae through enzymatic activity and gene regulation.

PLOS Pathogens · Apr 5, 2021Peer-reviewedMicrobiology

An infant mouse model of influenza virus transmission demonstrates the role of virus-specific shedding, humoral immunity, and sialidase expression by colonizing Streptococcus pneumoniae.

M. B. Ortigoza, S. Blaser, M. A. Zafar, A. Hammond, J. N. Weiser

This paper introduces an infant mouse model to study influenza virus transmission, showing that viral shedding, age, humoral immunity, and sialidase activity of Streptococcus pneumoniae influence transmission efficiency.

bioRxiv · Oct 31, 2018Microbiology