Author

K. M. Crosse

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Assay:proteomics· 3 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Approach:deep learning· 1 Research Focus:differential expression· 1

Frequent Co-Authors

E. A. Monson· 2 shared K. J. Helbig· 2 shared M. Dittmann· 2 shared R. Duerr· 2 shared A. B. Dumbrepatil· 1 shared A. Fisher· 1 shared A. M. Valero-Jimenez· 1 shared A. Schinlever· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersMicrobiology

E. A. Monson

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

In-silico docking platform with serine protease inhibitor (SERPIN) structures identifies host cysteine protease targets with significance for SARS-CoV-2

J. J. Rodriguez Galvan, M. de Vries, S. Belblidia, A. Fisher, R. A. Prescott, K. M. Crosse, W. F. Mangel, R. Duerr, M. Dittmann

The paper uses in-silico docking to identify SERPIN targets in SARS-CoV-2, finding novel interactions and validating their role in viral replication.

bioRxiv · Nov 18, 2022 · PreprintMicrobiology

A neonatal mouse model characterizes transmissibility of SARS-CoV-2 variants and reveals a role for ORF8

B. A. Rodriguez-Rodriguez, G. Ciabattoni, R. Duerr, A. M. Valero-Jimenez, S. T. Yeung, K. M. Crosse, A. Schinlever, L. Bernard-Raichon, J. J. Rodriguez-Galvan, M. McGrath, S. Vashee, Y. Xue, C. Loomis, K. M. Khanna, K. H. Cadwell, , M. Dittmann

This study establishes a neonatal mouse model to study SARS-CoV-2 transmissibility, showing variant differences in infectious shedding and identifying ORF8's role in transmission.

bioRxiv · Oct 4, 2022 · PreprintMicrobiology

Intracellular Lipid Droplet Accumulation Occurs Early Following Viral Infection and Is Required for an Efficient Interferon Response

E. A. Monson, K. M. Crosse, E. Duan, W. Chen, R. D. O'Shea, L. M. Wakem, D. R. Whelan, K. J. Helbig

The paper shows that lipid droplets form early after viral infection, support interferon production, and reduce viral replication.

Nature Communications · Jul 14, 2021Peer-reviewedMicrobiology

Viperin binds STING and enhances the type-I interferon response following dsDNA detection

K. M. Crosse, E. A. Monson, A. B. Dumbrepatil, M. Smith, Y.-Y. Tseng, K. H. Van der Hoek, P. A. Revill, D. C. Tscharke, E. N. G. Marsh, M. R. Beard, K. J. Helbig

This study identifies Viperin's role in enhancing the type-I interferon response by binding STING and promoting TBK1 ubiquitination, thereby strengthening antiviral immunity against dsDNA.

bioRxiv · Dec 17, 2019Immunology