Author

R. S. Herati

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Immunology· 6 Microbiology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cell type annotation· 6 Organism:human· 6 Research Focus:differential expression· 4 Assay:scRNA-seq· 4 Approach:statistical model· 4 Research Focus:clustering· 3 Approach:experimental assay· 3 Approach:deep learning· 2

Frequent Co-Authors

E. J. Wherry· 5 shared D. A. Oldridge· 3 shared S. Manne· 3 shared A. E. Baxter· 2 shared A. R. Greenplate· 2 shared D. Mathew· 2 shared J. R. Giles· 2 shared L. A. Vella· 2 shared

Activity by Year

2019-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

5 shared papersImmunology

E. J. Wherry

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Inflammation durably imprints memory CD4+ T cells

S. L. Gray-Gaillard, S. Solis, H. Chen, C. Monteiro, G. Ciabattoni, M. I. Samanovic, A. R. Cornelius, T. Williams, E. Geesey, M. Rodriguez, M. B. Ortigoza, E. N. Ivanova, S. B. Koralov, M. J. Mulligan, R. S. Herati

This study compares transcriptional and epigenetic differences in Spike-specific CD4+ T cell memory between individuals primed by SARS-CoV-2 infection versus mRNA vaccination.

bioRxiv · Nov 15, 2022 · PreprintImmunology

Human T follicular helper clones seed the germinal center-resident regulatory pool

C. Le Coz, D. A. Oldridge, R. S. Herati, N. De Luna, J. Garifallou, E. C. Cabrera, J. P. Belman, D. Pueschl, L. V. Silva, A. V. C. Knox, S. Yoon, K. B. Zur, S. D. Handler, H. Hakonarson, E. J. Wherry, , N. Romberg

The paper identifies human Tfr cells as either Treg-derived (nTfr) or Tfh-derived (iTfr) clones, with distinct functional and spatial characteristics.

bioRxiv · Oct 26, 2022Immunology

Induction of a CD8 T cell intrinsic DNA damage and repair response is associated with clinical response to PD-1 blockade in uterine cancer.

Y. Muroyama, S. Manne, N. Wellhausen, D. A. Oldridge, A. R. Greenplate, L. Chilukuri, D. Mathew, C. Xu, R. S. Herati, S. L. Berger, A. C. Huang, C. H. June, D. Zamarin, C. F. Friedman, E. J. Wherry

The paper identifies a CD8 T cell intrinsic DNA damage response linked to clinical response to PD-1 blockade in uterine cancer using high-dimensional single-cell analysis.

bioRxiv · Apr 16, 2022 · PreprintImmunology

Rapid induction of antigen-specific CD4+ T cells guides coordinated humoral and cellular immune responses to SARS-CoV-2 mRNA vaccination

M. M. Painter, D. Mathew, R. R. Goel, S. A. Apostolidis, A. Pattekar, O. Kuthuru, A. E. Baxter, R. S. Herati, D. A. Oldridge, S. Gouma, P. Hicks, S. Dysinger, K. A. Lundgreen, L. Kuri-Cervantes, S. Adamski, , E. J. Wherry

This study shows that mRNA vaccination rapidly induces antigen-specific CD4+ T cells, which coordinate humoral and cellular immune responses, with booster doses enhancing T cell responses in naive individuals.

bioRxiv · Apr 21, 2021 · PreprintImmunology

Neutralization of viruses with European, South African, and United States SARS-CoV-2 variant spike proteins by convalescent sera and BNT162b2 mRNA vaccine-elicited antibodies

T. Tada, B. M. Dcosta, M. Samanovic-Golden, R. S. Herati, A. Cornelius, M. J. Mulligan, N. R. Landau

This study evaluates the neutralizing activity of convalescent sera and BNT162b2 vaccine antibodies against SARS-CoV-2 variants, showing reduced efficacy against B.1.351 due to E484K mutation but overall maintained protection.

bioRxiv · Feb 5, 2021Microbiology

Chronic viral infection promotes early germinal center exit of B cells and impaired antibody development.

R. P. Staupe, L. A. Vella, S. Manne, J. R. Giles, W. Meng, R. S. Herati, O. Khan, J. E. Wu, A. E. Baxter, E. T. Luning Prak, E. J. Wherry

This study shows chronic viral infection disrupts GC B cell fate decisions, leading to early exit and impaired antibody development.

bioRxiv · Nov 21, 2019 · PreprintImmunology

Vaccine-induced ICOS+CD38+ cTfh are sensitive biosensors of age-related changes in inflammatory pathways

R. S. Herati, L. V. Silva, L. A. Vella, A. Muselman, C. Alanio, B. Bengsch, R. Kurupati, S. Kannan, S. Manne, A. Kossenkov, D. Canaday, S. Doyle, H. Ertl, K. Schmader, E. J. Wherry

The paper uses transcriptional profiling to show that vaccine-induced ICOS+CD38+ cTfh cells in elderly show inflammation-related gene signatures and age-associated biological changes.

bioRxiv · Jul 24, 2019 · PreprintImmunology