M. Balazova

Upregulation of the AMPK-FOXO1-PDK4 pathway is a primary mechanism of pyruvate dehydrogenase activity reduction and leads to increased glucose uptake in tafazzin-deficient cells

This study identifies the upregulation of the AMPK-FOXO1-PDK4 pathway as the mechanism causing reduced PDH activity and increased glucose uptake in tafazzin-deficient cells.

Two different phospholipases C, Isc1 and Pgc1, cooperate to regulate mitochondrial function

The paper shows that Isc1 and Pgc1 phospholipases cooperate to regulate mitochondrial function and lipid homeostasis through a feedback loop involving phosphatidylglycerol and diacylglycerol.

The lipid droplet protein Pgc1 controls the subcellular distribution of phosphatidylglycerol

The paper shows that Pgc1, a phosphatidylglycerol-specific phospholipase, is stored and regulated by lipid droplets to control PG distribution in yeast.