Endogenous GDF15 and FGF21 additively alleviate hepatic steatosis and insulin resistance in obese mice.
S. Patel, A. Haider, A. Alvarez-Guaita, G. Bidault, J. S. El-Sayed Moustafa, E. Guiu-Jurado, J. A. Tadross, J. Warner, J. Harrison, S. Virtue, F. Scurria, I. Zvetkova, M. Blüher, K. S. Small, S. O'Rahilly, D. B. Savage
This study shows that GDF15 and FGF21, secreted by the liver in obese mice, reduce hepatic steatosis and insulin resistance when both are active.
bioRxiv · Jun 8, 2022 · PreprintPhysiology