Author

A. Alvarez-Guaita

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Assay:electronic health records· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

A. Haider· 3 shared D. B. Savage· 3 shared S. Patel· 3 shared F. Scurria· 2 shared J. P. Mann· 2 shared J. Prudent· 2 shared R. K. Semple· 2 shared S. O'Rahilly· 2 shared

Activity by Year

2022-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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3 shared papersCell Biology

A. Haider

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Loss of Mfn1 but not Mfn2 enhances adipogenesis

J. P. Mann, L. Tabara, A. Alvarez-Guaita, L. Dong, A. Haider, K. Lim, P. Tandon, J. E. Minchin, S. O'Rahilly, S. Patel, D. J. Fazakerley, J. Prudent, R. K. Semple, D. B. Savage

The paper shows that loss of Mfn1 promotes adipogenesis in cultured cells, while loss of Mfn2 does not, indicating distinct roles for Mfn1 and Mfn2 in adipocyte differentiation.

bioRxiv · Nov 4, 2022 · PreprintCell Biology

A mouse model of human mitofusin 2-related lipodystrophy exhibits adipose-specific mitochondrial stress and reduced leptin secretion

J. P. Mann, X. Duan, A. Alvarez-Guaita, A. Haider, I. Luijten, M. Page, S. Patel, F. Scurria, M. Protasoni, L. C. Tabara, S. Virtue, S. I. O'Rahilly, M. Armstrong, J. Prudent, R. K. Semple, D. B. Savage

This study uses a mouse model to show that a MFN2 mutation causes adipose-specific mitochondrial stress and reduced leptin secretion, linking mitochondrial dysfunction to metabolic disease.

bioRxiv · Sep 20, 2022Cell Biology

Endogenous GDF15 and FGF21 additively alleviate hepatic steatosis and insulin resistance in obese mice.

S. Patel, A. Haider, A. Alvarez-Guaita, G. Bidault, J. S. El-Sayed Moustafa, E. Guiu-Jurado, J. A. Tadross, J. Warner, J. Harrison, S. Virtue, F. Scurria, I. Zvetkova, M. Blüher, K. S. Small, S. O'Rahilly, D. B. Savage

This study shows that GDF15 and FGF21, secreted by the liver in obese mice, reduce hepatic steatosis and insulin resistance when both are active.

bioRxiv · Jun 8, 2022 · PreprintPhysiology