A mechanistic switch from selective transporter to an ion channel impairs the filamentation signalling capability of ammonium transceptors in yeast
G. Williamson, A. S. Brito, A. Bizior, G. Tamburrino, G. D. Mirandela, T. Harris, P. A. Hoskisson, u. zachariae, A. M. Marini, M. Boeckstaens, A. Javelle
The paper shows that variations in the Twin-His motif of Amt-Mep transporters switch their function from selective transport to non-specific ion channel activity, impairing filamentation signaling in yeast.
bioRxiv · Aug 25, 2021 · PreprintMicrobiology