Mutation nsp6 L232F associated with MERS-CoV zoonotic transmission confers higher viral replication in human respiratory tract cultures ex-vivo
R. T. So, D. K. W. Chu, K. P. Y. Hui, C. K.-P. Mok, S. Sanyal, J. M. Nicholls, J. C. W. Ho, M. C. Cheung, K. C. NG, H. W. Yeung, M. C. W. Chan, L. L. M. Poon, J. Zhao, J. S. M. Peiris
This study identifies the nsp6 L232F mutation in MERS-CoV as enhancing viral replication in human respiratory tissues and mice, suggesting a role in human adaptation.
bioRxiv · Mar 27, 2023Microbiology