Author

J. S. M. Peiris

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Biochemistry· 1 Evolutionary Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 6 Organism:human· 5 Organism:mouse· 4 Assay:proteomics· 3 Research Focus:chromatin & epigenetic regulation· 1 Organism:rat· 1 Approach:statistical model· 1

Frequent Co-Authors

L. L. M. Poon· 3 shared N. C. Wu· 3 shared C. K. P. Mok· 2 shared D. K. W. Chu· 2 shared G. K. Yip· 2 shared H. Lv· 2 shared I. A. Wilson· 2 shared J. Zhao· 2 shared

Activity by Year

2020-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersMicrobiology

L. L. M. Poon

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Mutation nsp6 L232F associated with MERS-CoV zoonotic transmission confers higher viral replication in human respiratory tract cultures ex-vivo

R. T. So, D. K. W. Chu, K. P. Y. Hui, C. K.-P. Mok, S. Sanyal, J. M. Nicholls, J. C. W. Ho, M. C. Cheung, K. C. NG, H. W. Yeung, M. C. W. Chan, L. L. M. Poon, J. Zhao, J. S. M. Peiris

This study identifies the nsp6 L232F mutation in MERS-CoV as enhancing viral replication in human respiratory tissues and mice, suggesting a role in human adaptation.

bioRxiv · Mar 27, 2023Microbiology

Imprinted anti-hemagglutinin and anti-neuraminidase antibody responses after childhood infections of A(H1N1) and A(H1N1)pdm09 influenza viruses

P. Daulagala, B. Mann, K. Leung, E. Lau, L. Yung, R. Lei, S. I. N. Nizami, J. T. Wu, S. S. Chiu, R. S. Daniels, N. C. Wu, D. E. Wentworth, J. S. M. Peiris, H.-L. Yen

The paper characterizes anti-HA and anti-NA antibody responses to A(H1N1) and A(H1N1)pdm09 influenza viruses in individuals born between 1950-2015, finding age-dependent imprinting and cross-reactivity to multiple antigenic variants.

bioRxiv · Feb 1, 2023Microbiology

Surface-aerosol stability and pathogenicity of diverse MERS-CoV strains from 2012 - 2018

N. van Doremalen, M. C. Letko, R. Fischer, T. Bushmaker, K. C. Yinda, J. Schulz, S. N. Seifert, N. J. Kim, M. G. Hemida, G. Kayali, W. B. Park, R. Perera, A. Tamin, N. J. Thornburg, S. Tong, , V. Munster

The paper examines the environmental stability, replication kinetics, and pathogenicity of diverse MERS-CoV strains and SARS-CoV-2, finding variation in stability and pathogenicity among isolates.

bioRxiv · Feb 11, 2021 · PreprintMicrobiology

Characterization of SARS-CoV-2 N protein reveals multiple functional consequences of the C-terminal domain

C. Wu, A. J. Qavi, A. Hachim, N. Kavian, A. R. Cole, A. B. Moyle, N. D. Wagner, J. Sweeney-Gibbons, H. W. Rohrs, M. L. Gross, J. S. M. Peiris, C. F. Basler, C. W. Farnsworth, S. A. Valkenburg, G. K. Amarasinghe, D. W. Leung

This study characterizes the SARS-CoV-2 N protein, identifying domain-specific functions and highlighting the C-terminal domain's immunogenicity for diagnostic applications.

bioRxiv · Nov 30, 2020Biochemistry

Evidence of antigenic imprinting in sequential Sarbecovirus immunization

H. Lv, R. T. Y. So, M. Yuan, H. Liu, C.-C. D. Lee, G. K. Yip, W. W. Ng, I. A. Wilson, J. S. M. Peiris, N. C. Wu, C. K. P. Mok

This study shows that prior exposure to one Sarbecovirus strain biases antibody response to a subsequent, antigenically distinct strain, suggesting antigenic imprinting affects immunity to SARS-CoV-2.

bioRxiv · Oct 14, 2020 · PreprintImmunology

Cross-reactive antibody response between SARS-CoV-2 and SARS-CoV infections

H. Lv, N. C. Wu, O. T.-Y. Tsang, M. Yuan, R. A. P. M. Perera, W. S. Leung, R. T. Y. So, J. M. C. Chan, G. K. Yip, T. S. H. Chik, Y. Wang, C. Y. C. Choi, Y. Lin, W. W. Ng, J. Zhao, , C. K. P. Mok

This study examines cross-reactive antibody responses between SARS-CoV-2 and SARS-CoV, finding common binding but rare neutralization, suggesting non-neutralizing antibodies target conserved epitopes.

bioRxiv · Mar 15, 2020Microbiology

Multivariate Analyses of Codon Usage of SARS-CoV-2 and other betacoronaviruses

H. Gu, D. K. W. Chu, J. S. M. Peiris, L. L. M. Poon

This study analyzes codon usage patterns of SARS-CoV-2 and betacoronaviruses using multivariate methods, finding similar amino acid usage to bat and human SARSr-CoVs but distinct synonymous codon usage in spike and membrane genes.

bioRxiv · Feb 15, 2020Evolutionary Biology