Author

J. M. Nicholls

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Assay:spatial transcriptomics· 1

Frequent Co-Authors

A. Bezault· 1 shared B. Rodriguez de Francisco· 1 shared C. K.-P. Mok· 1 shared C. Sauvanet· 1 shared D. Hanein· 1 shared D. K. W. Chu· 1 shared H. W. Yeung· 1 shared J. C. W. Ho· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCell Biology

A. Bezault

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Mutation nsp6 L232F associated with MERS-CoV zoonotic transmission confers higher viral replication in human respiratory tract cultures ex-vivo

R. T. So, D. K. W. Chu, K. P. Y. Hui, C. K.-P. Mok, S. Sanyal, J. M. Nicholls, J. C. W. Ho, M. C. Cheung, K. C. NG, H. W. Yeung, M. C. W. Chan, L. L. M. Poon, J. Zhao, J. S. M. Peiris

This study identifies the nsp6 L232F mutation in MERS-CoV as enhancing viral replication in human respiratory tissues and mice, suggesting a role in human adaptation.

bioRxiv · Mar 27, 2023Microbiology

Novel ACE2 nanoparticles universally block SARS-CoV-2 variants in the human respiratory tract

C. Sauvanet, M. Lemos, A. Bezault, B. Rodriguez de Francisco, M. C. Chan, K. P. Hui, K.-c. Ng, J. M. Nicholls, N. Volkmann, D. Hanein

This study develops hACE2 nanoparticles that block SARS-CoV-2 and its variants by sequestering viruses through aggregation in cell systems and human respiratory tract explants.

bioRxiv · May 5, 2022 · PreprintCell Biology