Rare SH2B3 coding variants identified in lupus patients impair B cell tolerance and predispose to autoimmunity
Y. Zhang, R. Morris, A. M. D. Lorenzo, X. Meng, N. J. Kershaw, P. Kiridena, G. J. Brown, G. Burgio, J. Y. Cappello, Q. Shen, H. Wang, C. M. Turnbull, T. Lea-Henry, M. Stanley, Z. Yu, , J. I. Ellyard
The paper identifies rare SH2B3 variants in lupus patients that impair B cell tolerance and increase autoimmunity risk by affecting IL-4R signaling and BAFF-R expression.
bioRxiv · Apr 27, 2023 · PreprintImmunology