Author

M. C. Jensen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Valdez· 2 shared B. C. Curtis· 2 shared C. H. Spurrell· 2 shared C. P. Saxby· 2 shared J. M. Rosser· 2 shared A. J. Johnson· 1 shared A. L. Wilson· 1 shared A. M. Lande· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersImmunology

A. Valdez

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Genome-wide CRISPRa screens nominate modulators of CAR T cell survival within distinct tumor cytokine milieus

B. C. Curtis, C. H. Spurrell, L. Flint, A. M. Lande, M. Leonardi, J. M. Rosser, A. Valdez, N. Murren, T. Chai, M. Fitzgerald, J. Martinez-Reyes, C. P. Saxby, S. K. Oda, M. C. Jensen

This paper develops a CRISPRa-based method to identify genes enhancing CAR T cell survival in different tumor environments.

bioRxiv · Mar 16, 2024 · PreprintImmunology

Rationally designed modular STAT-activating scaffolds enforce cell-intrinsic transcriptional programs augmenting the anti-tumor potency of CAR T cells

C. P. Saxby, T. K. Ishida, J. M. Rosser, B. C. Curtis, M. L. Baldwin, C. H. Spurrell, J. Giles, A. Valdez, A. J. Johnson, J. Gustafson, J. S. Appelbaum, M. C. Jensen

This study designs and tests STAT-activating scaffolds to enhance CAR T cell anti-tumor potency, finding that LASI-3 improves function without lymphoproliferative side effects.

bioRxiv · Dec 22, 2023 · PreprintBioengineering

State-dependent protein-protein interactions mediating 4-1BB CAR Signaling

S. A. Ritmeester-Loy, J. D. Lautz, Y. Zhang-Wong, J. A. Gustafson, A. L. Wilson, C. Lin, P. R. Gafken, M. C. Jensen, R. Orentas, S. E. Smith

The paper identifies a network of protein interactions activated by 4-1BB CARs upon target engagement and shows that network activation magnitude correlates with IL-2 secretion.

bioRxiv · Jun 7, 2022 · PreprintImmunology