Author

A. Valdez

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Bioengineering· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Organism:fungi (other)· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

B. C. Curtis· 2 shared C. H. Spurrell· 2 shared C. P. Saxby· 2 shared J. M. Rosser· 2 shared M. C. Jensen· 2 shared A. Addetia· 1 shared A. C. Walls· 1 shared A. Dosey· 1 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersImmunology

B. C. Curtis

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Genome-wide CRISPRa screens nominate modulators of CAR T cell survival within distinct tumor cytokine milieus

B. C. Curtis, C. H. Spurrell, L. Flint, A. M. Lande, M. Leonardi, J. M. Rosser, A. Valdez, N. Murren, T. Chai, M. Fitzgerald, J. Martinez-Reyes, C. P. Saxby, S. K. Oda, M. C. Jensen

This paper develops a CRISPRa-based method to identify genes enhancing CAR T cell survival in different tumor environments.

bioRxiv · Mar 16, 2024 · PreprintImmunology

Protein nanoparticle vaccines induce potent neutralizing antibody responses against MERS-CoV

C. W. Chao, K. R. Sprouse, M. C. Miranda, N. J. Catanzaro, M. L. Hubbard, A. Addetia, C. Stewart, J. T. Brown, A. Dosey, A. Valdez, R. Ravichandran, G. G. Hendricks, M. Ahlrichs, C. Dobbins, A. Hand, , N. P. King

This study develops MERS-CoV vaccines using a protein nanoparticle platform, showing they induce strong neutralizing antibodies and protect mice against MERS-CoV challenge.

bioRxiv · Mar 13, 2024Immunology

Rationally designed modular STAT-activating scaffolds enforce cell-intrinsic transcriptional programs augmenting the anti-tumor potency of CAR T cells

C. P. Saxby, T. K. Ishida, J. M. Rosser, B. C. Curtis, M. L. Baldwin, C. H. Spurrell, J. Giles, A. Valdez, A. J. Johnson, J. Gustafson, J. S. Appelbaum, M. C. Jensen

This study designs and tests STAT-activating scaffolds to enhance CAR T cell anti-tumor potency, finding that LASI-3 improves function without lymphoproliferative side effects.

bioRxiv · Dec 22, 2023 · PreprintBioengineering

Extracellular vesicle formation in Cryptococcus deuterogattii impacts fungal virulence and requires the NOP16 gene

R. Castelli, A. Pereira, L. Honorato, A. Valdez, H. C. de Oliveira, J. M. Bazioli, A. W. A. Garcia, T. Klimeck, F. Reis, C. C. Staats, L. Nimrichter, t. P. Fill, M. Rodrigues

This study shows that NOP16 is required for extracellular vesicle formation in Cryptococcus deuterogattii, and EV composition affects fungal virulence.

bioRxiv · Jun 6, 2022Microbiology