M. C. Lagomarsino

This study directly observes two distinct E. coli cell cycle oscillators at the single-cell level, revealing their relationship with cell size and DNA replication initiation.

The paper measures single-cell volume growth in HeLa cells and finds it is exponential during most of the cell cycle with higher rates in S-G2 than G1, attributing variability to additive noise rather than fluctuations in growth rate.

The paper shows that drug treatment induces colorectal cancer persister cells with significantly increased mutation rates, suggesting new strategies to prevent tumor recurrence.